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Article

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis.

Critical care (London, England) - 28 Jun 2012

Boomer Jonathan S, Shuherk-Shaffer Jennifer, Hotchkiss Richard S, Green Jonathan M

Abstract excerpt

INTRODUCTION: Severe sepsis is characterized by an initial hyper-inflammatory response that may progress to an immune-suppressed state associated with increased susceptibility to nosocomial infection. Analysis of samples obtained from patients who died of sepsis has identified expression of specific inhibitory receptors expressed on lymphocytes that are associated with cell exhaustion. The objective of this study...

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Source

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Identifiers

PMID: 22742734
DOI: 10.1186/cc11404
PMCID: PMC3580670

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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