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Article

Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors.

Frontiers in immunology - 1 Jan 2021

Lu Jie, Sun Kun, Yang Huiping, Fan Dan, Huang He, Hong Yi, Wu Shuiyan, Zhou HuiTing, Fang Fang, Li YanHong, Meng Lijun, Huang Jie, Bai Zhenjiang

Abstract excerpt

Background: Sepsis is a complex systemic immune dysfunction syndrome induced by infection. Sepsis has a high mortality rate, with most patients dying due to systemic organ failure or secondary infection. Dendritic cells (DCs) are professional antigen-presenting cells. Upon infection with microbes, DCs are activated to induce adaptive immune responses for controlling infection. DC generation and function are...

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Identifiers

PMID: 34566996
DOI: 10.3389/fimmu.2021.732612
PMCID: PMC8458800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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