Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.

Journal of biomedical science - 15 Jul 2009

Khanna Ashwani K

Abstract excerpt

Cyclin kinase inhibitor p21 is one of the most potent inhibitors of aortic smooth muscle cell proliferation, a key mediator of atherosclerosis. This study tests if p2l deficiency will result in severe atherosclerosis in a mouse model. p21-/- and strain matched wild type mice were fed with high fa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Feed
Share to Aorta
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD36 Antigens

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Heme Oxygenase-1

Share to Lipids

Share to NADPH Oxidases

Source

Open in PubMed Open full text

Identifiers

PMID: 19604372
DOI: 10.1186/1423-0127-16-66
PMCID: PMC2720941

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19604372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.PMID 19604372Read ↗

Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.Semantic proximity Read ↗

Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice.Semantic proximity Read ↗

Mutated p21/WAF/CIP transgene overexpression reduces smooth muscle cell proliferation, macrophage deposition, oxidation-sensitive mechanisms, and restenosis in hypercholesterolemic apolipoprotein E knockout mice.Semantic proximity Read ↗

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.Semantic proximity Read ↗

Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation.Semantic proximity Read ↗

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.Semantic proximity Read ↗

p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and CarcinogenesisSemantic proximity Read ↗

UGP2, a novel target gene of TP53, inhibits endothelial cells apoptosis and atherosclerosisSemantic proximity Read ↗

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.Semantic proximity Read ↗

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.Semantic proximity Read ↗

The growth suppressor p27 <sup>Kip1</sup> protects against diet‐induced atherosclerosisSemantic proximity Read ↗

p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.