Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury

14 Oct 2024

Abstract excerpt

The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39402059
DOI: 10.1038/s41514-024-00175-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injuryPMID 39402059Read ↗

Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilationSemantic proximity Read ↗

Mechanical Ventilation induced DNA Damage and P21 in an Acute Aging Model of Lung InjurySemantic proximity Read ↗

The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathwaySemantic proximity Read ↗

Differential regulation of p21 by p53 and Rb in cellular response to oxidative stressSemantic proximity Read ↗

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.Semantic proximity Read ↗

Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.Semantic proximity Read ↗

Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis.Semantic proximity Read ↗

The role of p21 in cellular senescence and aging-related diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.