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Article

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.

Circulation research - 19 Mar 2004

Brühl Tom, Heeschen Christopher, Aicher Alexandra, Jadidi Amir S, Haendeler Judith, Hoffmann Jörg, Schneider Michael D, Zeiher Andreas M, Dimmeler Stefanie, Rössig Lothar

Abstract excerpt

p21(Cip1) (p21) controls cell cycle progression and apoptosis in mature endothelial cells (ECs) and regulates size and cycling of the hematopoietic progenitor cell pool. Because circulating endothelial progenitor cells (EPCs) contribute to postnatal neovascularization in addition to mature ECs, we investigated the regulation of ECs and EPCs in p21-deficient mice. Mature aortic EC proliferation was increased in...

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PMID: 14752032
DOI: 10.1161/01.RES.0000119922.71855.56

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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