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Article

Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice.

Cardiovascular diabetology - 11 Jun 2015

Yan Xiaoqing, Chen Jun, Zhang Chi, Zeng Jun, Zhou Shanshan, Zhang Zhiguo, Lu Xuemian, Chen Jing, Feng Wenke, Li Xiaokun, Tan Yi

Abstract excerpt

Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes. The effect of FGF21 on the development and progression of diabetes-induced pathogenic changes in the aorta has not currently been addressed. To characterize these effects, type 1 diabetes was induced in both FGF21 knockout (FGF21KO) and C57BL/6 J wild type...

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Identifiers

PMID: 27391008
DOI: 10.1186/s12933-015-0241-0
PMCID: PMC4484638

Genes

FGF21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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