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Article

Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study.

Journal of endocrinological investigation - 1 Nov 2012

Grassetti D, Paoli D, Gallo M, D'Ambrosio A, Lombardo F, Lenzi A, Gandini L

Abstract excerpt

BACKGROUND: Correct histone/protamine replacement is an important stage in chromatin condensation during spermiogenesis in humans. There are two types of protamines: protamine 1 (P1) and the protamine 2 family (P2, P3, and P4), coded by the genes PRM1 and PRM2. AIM: We analyze the sequences and gene expression of PRM1 and PRM2 and their relationship with defective spermatogenesis. MATERIALS AND METHODS: Sequence...

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Source

Identifiers

PMID: 22104739
DOI: 10.3275/8111

Genes

PRM1
PRM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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