Article
A non-canonical role for p27Kip1 in restricting proliferation of corneal endothelial cells during development.
PloS one - 1 Jan 2020
Defoe Dennis M, Rao Huiying, Harris David J, Moore Preston D, Brocher Jan, Harrison Theresa A
Abstract excerpt
The cell cycle regulator p27Kip1 is a critical factor controlling cell number in many lineages. While its anti-proliferative effects are well-established, the extent to which this is a result of its function as a cyclin-dependent kinase (CDK) inhibitor or through other known molecular interactions is not clear. To genetically dissect its role in the developing corneal endothelium, we examined mice harboring two...
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