Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus.

The international journal of biochemistry & cell biology - 1 Jul 2017

Sreedhar Remya, Arumugam Somasundaram, Thandavarayan Rajarajan A, Karuppagounder Vengadeshprabhu, Koga Yusuke, Nakamura Takashi, Harima Meilei, Watanabe Kenichi

Abstract excerpt

Diabetic cardiomyopathy (DCM), a metabolic disorder, is one of the leading causes of mortality around the world and its pathogenesis involves cardiac inflammation and altered metabolic profile. Altered fatty acid metabolism during DCM can cause macrophage polarization in which inflammatory M1 phenotype dominates over the anti-inflammatory M2 phenotype. Hence, it is essential to identify a specific target, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Alanine Transaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartate Aminotransferases

Share to Diet, High-Fat

Share to Fatty Acids

Share to Macrophages

Share to Myocardium

Share to Oxidation-Reduction

Source

Identifiers

PMID: 28483670
DOI: 10.1016/j.biocel.2017.05.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus.PMID 28483670Read ↗

The role and therapeutic potential of macrophages in the pathogenesis of diabetic cardiomyopathySemantic proximity Read ↗

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read ↗

Molecular Dysfunction and Phenotypic Derangement in Diabetic CardiomyopathySemantic proximity Read ↗

Linking Fatty Acid Metabolism to Diabetic Cardiomyopathy: The Role of Mitochondrial Dysfunction and Immune Microenvironment Alterations, a Bioinformatics ApproachSemantic proximity Read ↗

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes.Semantic proximity Read ↗

Prohibitin overexpression improves myocardial function in diabetic cardiomyopathySemantic proximity Read ↗

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.Semantic proximity Read ↗

The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats.Semantic proximity Read ↗

High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes.Semantic proximity Read ↗

Potential role of the mTOR-C1-PGC1α-PPARα axis under type-II diabetes and hypertension in the human heartSemantic proximity Read ↗

Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactionsSemantic proximity Read ↗

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.