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Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome.

Blood cells, molecules & diseases - 1 Jan 2000

Greene Marianne E, Mundschau Gina, Wechsler Joshua, McDevitt Michael, Gamis Alan, Karp Judith, Gurbuxani Sandeep, Arceci Robert, Crispino John D

Abstract excerpt

Mutations in transcription factors often contribute to human leukemias by providing a block to normal differentiation. To determine whether mutations in the hematopoietic transcription factor GATA1 are associated with leukemia, we assayed for alterations in the GATA1 gene in bone marrow samples from patients with various subtypes of acute leukemia. Here we summarize our findings that GATA1 is mutated in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Megakaryoblastic, Acute

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Source

Identifiers

PMID: 14636651
DOI: 10.1016/j.bcmd.2003.08.001

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome.PMID 14636651Read ↗

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