Article
Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome.
Blood cells, molecules & diseases - 1 Jan 2000
Greene Marianne E, Mundschau Gina, Wechsler Joshua, McDevitt Michael, Gamis Alan, Karp Judith, Gurbuxani Sandeep, Arceci Robert, Crispino John D
Abstract excerpt
Mutations in transcription factors often contribute to human leukemias by providing a block to normal differentiation. To determine whether mutations in the hematopoietic transcription factor GATA1 are associated with leukemia, we assayed for alterations in the GATA1 gene in bone marrow samples from patients with various subtypes of acute leukemia. Here we summarize our findings that GATA1 is mutated in the...
Topics
- Bone Marrow
- DNA Mutational Analysis
- DNA-Binding Proteins
- Disease Progression
- Down Syndrome
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Humans
- Leukemia, Megakaryoblastic, Acute
- Mutation
- Myeloproliferative Disorders
- Transcription Factors