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Article

ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.

Journal of clinical psychopharmacology - 1 Aug 2009

Jaquenoud Sirot Eveline, Knezevic Branka, Morena Gina Perla, Harenberg Sabine, Oneda Beatrice, Crettol Séverine, Ansermot Nicolas, Baumann Pierre, Eap Chin B

Abstract excerpt

To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and phenotyped for CYP1A2 and CYP3A activity. CYP1A2 activity and dose-corrected trough steady-state plasma concentrations of clozapine correlated significantly (r = -0.61; P = 1 x 10), with no influence of the CYP1A2*1F genotype (P = 0.38). CYP2C19 poor...

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Source

Identifiers

PMID: 19593168
DOI: 10.1097/JCP.0b013e3181acc372

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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