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Article

Genetic and Clinical Factors Affecting Plasma Clozapine Concentration

19 Feb 2015

Abstract excerpt

OBJECTIVE: To assess (1) the variance of plasma clozapine levels; (2) the relative importance of sex, smoking habits, weight, age, and specific genetic variants of cytochrome P450 1A2 (CYP1A2), uridine diphosphate glucuronosyltransferase 1A4 (UGT1A4), and multidrug resistance protein 1 (MDR1) on plasma levels of clozapine; and (3) the relation between plasma clozapine levels, fasting glucose levels, and waist...

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PMID: 26137357
DOI: 10.4088/pcc.14m01704

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