Article
Population pharmacokinetic analysis of mirtazapine.
European journal of clinical pharmacology - 1 Sept 2004
Grasmäder Katja, Verwohlt Petra Louise, Kühn Kai-Uwe, Dragicevic Aleksandra, von Widdern Olrik, Zobel Astrid, Hiemke Christoph, Rietschel Marcella, Maier Wolfgang, Jaehde Ulrich, Rao Marie Luise
Abstract excerpt
OBJECTIVE: Mirtazapine belongs to the new generation of antidepressants that is commonly used in clinical routine. Therefore, we feel it mandatory to control compliance in the context of non-response, adverse events or other clinical situations by means of plasma concentration measurements. While controlled clinical studies have evaluated the effect of individual covariates on the pharmacokinetics of mirtazapine,...
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