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Article

ABCB1 polymorphisms are associated with clozapine plasma levels in psychotic patients.

Pharmacogenomics - 1 Aug 2009

Consoli Giorgio, Lastella Marianna, Ciapparelli Antonio, Catena Dell'Osso Mario, Ciofi Laura, Guidotti Emanuele, Danesi Romano, Dell'Osso Liliana, Del Tacca Mario, Di Paolo Antonello

Abstract excerpt

AIMS: ABCB1 is a transmembrane transporter that is expressed in excretory organs (kidneys and liver), in intestine mucosa and on the blood-brain barrier. Because of the particular distribution of the protein, the activity of ABCB1 may significantly affect drug pharmacokinetics during absorption and distribution. Of note, several SNPs of ABCB1 are known and many of them affect transporter activity and/or...

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Share to Antipsychotic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 19663671
DOI: 10.2217/pgs.09.51

Genes

ABCB1

Variants

Provenance

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