Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics.

The international journal of neuropsychopharmacology - 1 Jul 2017

Tóth Katalin, Csukly Gábor, Sirok Dávid, Belic Ales, Kiss Ádám, Háfra Edit, Déri Máté, Menus Ádám, Bitter István, Monostory Katalin

Abstract excerpt

Background: The atypical antipsychotic clozapine is effective in treatment-resistant schizophrenia; however, the success or failure of clozapine therapy is substantially affected by the variables that impact the clozapine blood concentration. Thus, elucidating the inter-individual differences in clozapine pharmacokinetics can facilitate the personalized therapy. Methods: Since a potential role in clozapine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clozapine

Share to Cytochrome P-450 CYP3A

Share to Psychotic Disorders

Share to RNA, Messenger

Share to Schizophrenia

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28340122
DOI: 10.1093/ijnp/pyx019
PMCID: PMC5492788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics.PMID 28340122Read ↗

ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.Semantic proximity Read ↗

Clinical and genetic influencing factors on clozapine pharmacokinetics in Tunisian schizophrenic patients.Semantic proximity Read ↗

Optimization of Clonazepam Therapy Adjusted to Patient’s CYP3A Status andNAT2GenotypeSemantic proximity Read ↗

Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response.Semantic proximity Read ↗

The Role of Pharmacogenetic Testing in Optimizing Antipsychotic TherapySemantic proximity Read ↗

Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an updateSemantic proximity Read ↗

Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers.Semantic proximity Read ↗

CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients.Semantic proximity Read ↗

Alcohol intake potentiates clozapine adverse effects associated to CYP1A2*1C in patients with refractory psychosis.Semantic proximity Read ↗

Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspectsSemantic proximity Read ↗

CYP2D6 Genotypes Do Not Affect Clozapine Levels in a Large, Multicenter Cohort: Time Has Come to Revise Food and Drug Administration's Clozapine Packet Insert.Semantic proximity Read ↗

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.