Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms.

CNS & neurological disorders drug targets - 1 Jan 2024

Riffi Rachda, Boughrara Wefa, Chentouf Amina, Ilias Wassila, Brahim Narimene Malika Taieb, Berrebbah Amel Alioua, Belhoucine Fatma

Abstract excerpt

BACKGROUND AND OBJECTIVE: The association between carbamazepine (CBZ) metabolism and resistance in epilepsy and the genetic polymorphisms of CYP3A5 (rs776746 and rs15524) and CYP3A4 (rs2242480, rs2740574, rs35599367, rs12721627, and ) has been the subject of previous investigations with controversial results. Hence, we conducted a systematic review to assess the potential link between these...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Carbamazepine
Share to Cytochrome P-450 CYP3A
Share to Epilepsy
Share to CYP3A4 gene
Share to CYP3A5 gene
Share to Pharmacogenetics
Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 38859787
DOI: 10.2174/0118715273298953240529100325

Genes

CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms.PMID 38859787Read ↗

Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis.Semantic proximity Read ↗

Associations between<i>CYP3A4, CYP3A5</i>and<i>SCN1A</i>Polymorphisms and Carbamazepine Metabolism in Epilepsy: A Meta-analysisSemantic proximity Read ↗

Association of ABCB1 polymorphisms with carbamazepine metabolism and resistance in epilepsy: A meta-analysis.Semantic proximity Read ↗

Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.Semantic proximity Read ↗

Effect of CYP3A5 genotypes on the pharmacokinetics of carbamazepine when used as monotherapy or co-administered with phenytoin, phenobarbital or valproic acid in Thai patients.Semantic proximity Read ↗

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.Semantic proximity Read ↗

ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.Semantic proximity Read ↗

Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy.Semantic proximity Read ↗

Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization.Semantic proximity Read ↗

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.Semantic proximity Read ↗

Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients.Semantic proximity Read ↗

Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.