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Article

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo.

Current drug metabolism - 1 Jan 2022

Smith Robert Løvsletten, Wollmann Birgit M, Kausberg Marianne, Mæland Sondre, Tveito Marit, O'Connell Kevin, Molden Espen, Kringen Marianne Kristiansen

Abstract excerpt

BACKGROUND: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is unclear. OBJECTIVE: The objective of this study was to investigate the impact of UGT2B haplotype and UGT1A4*3 allele variants on the formation of CLZ glucuronide metabolites (5N- and...

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PMID: 35105285
DOI: 10.2174/1389200223666220201152953

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