Article
Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria.
Journal of bacteriology - 1 Sept 2009
Guttilla Irene K, Gaspar Andrew H, Swierczynski Arlene, Swaminathan Anu, Dwivedi Prabhat, Das Asis, Ton-That Hung
Abstract excerpt
In gram-positive bacteria, covalently linked pilus polymers are assembled by a specific transpeptidase enzyme called pilus-specific sortase. This sortase is postulated to cleave the LPXTG motif of a pilin precursor between threonine and glycine and to form an acyl enzyme intermediate with the substrate. Pilus polymerization is believed to occur through the resolution of this intermediate upon specific...
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