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Article

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Journal of bacteriology - 1 Oct 2013

Nielsen Hailyn V, Flores-Mireles Ana L, Kau Andrew L, Kline Kimberly A, Pinkner Jerome S, Neiers Fabrice, Normark Staffan, Henriques-Normark Birgitta, Caparon Michael G, Hultgren Scott J

Abstract excerpt

Enterococci commonly cause hospital-acquired infections, such as infective endocarditis and catheter-associated urinary tract infections. In animal models of these infections, a long hairlike extracellular protein fiber known as the endocarditis- and biofilm-associated (Ebp) pilus is an important virulence factor for Enterococcus faecalis. For Ebp and other sortase-assembled pili, the pilus-associated sortases...

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Identifiers

PMID: 23913319
DOI: 10.1128/JB.00451-13
PMCID: PMC3807452

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