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Article

Assembly Mechanism of FCT Region Type 1 Pili in Serotype M6 Streptococcus pyogenes

1 Sept 2011

Abstract excerpt

The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. We investigated the assembly mechanism of FCT type 1 pili in a serotype M6 strain. The pili were found to be assembled from two precursor proteins, the backbone protein T6 and ancillary protein FctX, and anchored to the cell wall in a manner that requires both a housekeeping sortase enzyme (SrtA) and pilus-associated...

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PMID: 21880740
DOI: 10.1074/jbc.m111.239780

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