Back to search

Article

The Basal and Major Pilins in the <i>Corynebacterium diphtheriae</i> SpaA Pilus Adopt Similar Structures that Competitively React with the Pilin Polymerase

2023-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Many species of pathogenic gram-positive bacteria display covalently crosslinked protein polymers (called pili or fimbriae) that mediate microbial adhesion to host tissues. These structures are assembled by pilus-specific sortase enzymes that join the pilin components together via lysine-isopeptide bonds. The archetypal SpaA pilus from Corynebacterium diphtheriae is built by the Cd SrtA pilus-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c4065405-17a0-5abf-b7a7-e49c07370d56
DOI
10.1101/2023.02.23.529612
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Basal and Major Pilins in the <i>Corynebacterium diphtheriae</i> SpaA Pilus Adopt Similar Structures that Competitively React with the Pilin PolymeraseDOI 10.1101/2023.02.23.529612
Kinetics and Optimization of the Lysine-Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae.Semantic proximity
A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence.Semantic proximity
Type IV pili-associated secretion of a biofilm matrix protein from <i>Clostridium perfringens</i> that forms intermolecular isopeptide bondsSemantic proximity
Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria.Semantic proximity
A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction.Semantic proximity
Linkage of T3 and Cpa pilins in the <i>Streptococcus pyogenes</i> M3 pilusSemantic proximity
Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1.Semantic proximity
Full structure/function analysis of all the pilin subunits in a type 4 pilus: a complex of minor pilins in <i>Streptococcus sanguinis</i> mediates binding to glycansSemantic proximity
Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.Semantic proximity
Group B Streptococcus pilus sortase regulation: a single mutation in the lid region induces pilin protein polymerization in vitro.Semantic proximity
<i>In situ</i> Architecture of the Tad Pilus Machine in <i>Caulobacter crescentus</i>Semantic proximity
DNA-uptake pilus of <i>Vibrio cholerae</i> capable of kin-discriminated auto-aggregationSemantic proximity
Select a neighboring publication to make it the new centre.