Article
Linkage of T3 and Cpa pilins in the <i>Streptococcus pyogenes</i> M3 pilus
11 May 2009
Abstract excerpt
The important human pathogen Streptococcus pyogenes (group A streptococcus, GAS) initiates infection by pilus-mediated attachment to host tissue. Thus, the pilus is an excellent target for design of anti-infective strategies. The T3 pilus of GAS is composed of multiple covalently linked subunits of the T3 protein to which the two minor pilins, Cpa and OrfB, are covalently attached. Because the proteins of GAS...
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