Article
Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells.
PloS one - 9 Jul 2009
Narayan Kedar, Perkins Edward M, Murphy Gavin E, Dalai Sarat K, Edidin Michael, Subramaniam Sriram, Sadegh-Nasseri Scheherazade
Abstract excerpt
The superantigen SEA causes non-specific hyperactivation of T and B cells at low concentrations. Studies of mutants or soluble proteins suggest SEA is bivalent for its ligand, MHC class II. However, the interaction between these molecules on intact cells is unknown. On primary mouse B cells expressing the MHC class II allele HLA-DR1, measurements of Förster Resonance Energy Transfer between HLA-DR1 molecules on...
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