A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

doi:10.1161/CIRCGENETICS.108.833806

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Article

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

Circulation. Cardiovascular genetics - 1 Aug 2009

Marroni Fabio, Pfeufer Arne, Aulchenko Yurii S, Franklin Christopher S, Isaacs Aaron, Pichler Irene, Wild Sarah H, Oostra Ben A, Wright Alan F, Campbell Harry, Witteman Jacqueline C, Kääb Stefan, Hicks Andrew A, Gyllensten Ulf, Rudan Igor, Meitinger Thomas, Pattaro Cristian, van Duijn Cornelia M, Wilson James F, Pramstaller Peter P

Abstract excerpt

BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within...

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PMID: 20031603
DOI: 10.1161/CIRCGENETICS.108.833806
PMCID: PMC2760953

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