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Article

Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study.

Circulation research - 1 Apr 2005

Pfeufer Arne, Jalilzadeh Shapour, Perz Siegfried, Mueller Jakob C, Hinterseer Martin, Illig Thomas, Akyol Mahmut, Huth Cornelia, Schöpfer-Wendels Andreas, Kuch Bernhard, Steinbeck Gerhard, Holle Rolf, Näbauer Michael, Wichmann H-Erich, Meitinger Thomas, Kääb Stefan

Abstract excerpt

Altered myocardial repolarization is one of the important substrates of ventricular tachycardia and fibrillation. The influence of rare gene variants on repolarization is evident in familial long QT syndrome. To investigate the influence of common gene variants on the QT interval we performed a linkage disequilibrium based SNP association study of four candidate genes. Using a two-step design we analyzed 174 SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15746444
DOI: 10.1161/01.RES.0000161077.53751.e6

Genes

KCNH2
KCNQ1

Variants

rs1805123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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