Article
Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation.
Nucleic acids research - 1 Sept 2009
Wan Lin, Sun Kelian, Ding Qi, Cui Yuehua, Li Ming, Wen Yalu, Elston Robert C, Qian Minping, Fu Wenjiang J
Abstract excerpt
Affymetrix SNP arrays have been widely used for single-nucleotide polymorphism (SNP) genotype calling and DNA copy number variation inference. Although numerous methods have achieved high accuracy in these fields, most studies have paid little attention to the modeling of hybridization of probes to off-target allele sequences, which can affect the accuracy greatly. In this study, we address this issue and...
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