Catching the genomic wave in oligonucleotide single-nucleotide polymorphism arrays by modeling sequence binding.

Abstract excerpt

The genomic wave has been identified as a major artifact in genome data and is highly correlated with the sequence GC content. Although statistical methods have been developed to filter this artifact, the mechanism underlying the genomic wave has not been studied yet. Understanding of the artifact, specifically the sources of the artifact, may lead to successful separation of biological signals from the artifact...

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