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Article

Mismatch and G-stack modulated probe signals on SNP microarrays.

PloS one - 17 Nov 2009

Binder Hans, Fasold Mario, Glomb Torsten

Abstract excerpt

BACKGROUND: Single nucleotide polymorphism (SNP) arrays are important tools widely used for genotyping and copy number estimation. This technology utilizes the specific affinity of fragmented DNA for binding to surface-attached oligonucleotide DNA probes. We analyze the variability of the probe signals of Affymetrix GeneChip SNP arrays as a function of the probe sequence to identify relevant sequence motifs which...

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PMID: 19924253
DOI: 10.1371/journal.pone.0007862
PMCID: PMC2775684

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