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Article

Estimating genome-wide copy number using allele-specific mixture models.

Journal of computational biology : a journal of computational molecular cell biology - 1 Sept 2008

Wang Wenyi, Carvalho Benilton, Miller Nathaniel D, Pevsner Jonathan, Chakravarti Aravinda, Irizarry Rafael A

Abstract excerpt

Genomic changes such as copy number alterations are one of the major underlying causes of human phenotypic variation among normal and disease subjects. Array comparative genomic hybridization (CGH) technology was developed to detect copy number changes in a high-throughput fashion. However, this technology provides only a >30-kb resolution, which limits the ability to detect copy number alterations spanning small...

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Identifiers

PMID: 18707534
DOI: 10.1089/cmb.2007.0148
PMCID: PMC2612042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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