Theoretical aspects of genomic variation screening using DNA microarrays.

doi:10.1002/bip.20008

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Article

Theoretical aspects of genomic variation screening using DNA microarrays.

Biopolymers - 5 Apr 2004

Vainrub Arnold, Pettitt B Montgomery

Abstract excerpt

We present a theoretical model for typical microarray-based single nucleotide polymorphism (SNP) assay of small genomic DNA amount. We derived the adsorption isotherm expressing the on-array hybridization efficiency in terms of genomic target sequence and concentration, oligonucleotide probe sequence and surface density, hybridization buffer, and temperature. This isotherm correctly describes the surface probe...

Topics

Genetic Testing
Genomics
Models, Theoretical
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 15048785
DOI: 10.1002/bip.20008

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