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Article

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype

12 Nov 2018

Abstract excerpt

BACKGROUND & AIMS: Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance . SH is morphologically characterized by steatosis , liver cell ballooning, cytoplasmic aggregates termed Mallory-Denk bodies (MDBs), inflammation, and fibrosis at late stage. Disturbance of the keratin cytoskeleton and aggregation of keratins (KRTs) are essential for MDB formation....

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PMID: 30439626
DOI: 10.1016/j.tranon.2018.10.010

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