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Article

Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2009

Gui T, Reheman A, Ni H, Gross P L, Yin F, Monroe D, Monahan P E, Stafford D W

Abstract excerpt

BACKGROUND: Factor IX binds to collagen type IV, but this binding has no known consequence. OBJECTIVES: To determine the effect of reduced binding of FIX to collagen IV. METHODS: We constructed and characterized 'knock-in' mice containing the mutation lysine 5 to alanine (K5A) in the Gla domain of their FIX. The K5A mutation dramatically reduced the affinity of FIX for collagen type IV, but had no measurable...

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Identifiers

PMID: 19583826
DOI: 10.1111/j.1538-7836.2009.03545.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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