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Article

Creation of a mouse expressing defective human factor IX.

Blood - 15 Sept 2004

Jin Da-Yun, Zhang Tai-Ping, Gui Tong, Stafford Darrel W, Monahan Paul E

Abstract excerpt

The majority of cases of human hemophilia B are the result of missense mutations in the coagulation factor IX gene and defective circulating factor IX is detectable in most patients. The available mouse factor IX knockout models of hemophilia B (FIXKO mouse) reproduce the bleeding phenotype of human hemophilia B, but because the models produce no factor IX they fail to reproduce the dominant human phenotype. We...

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Source

Identifiers

PMID: 15178576
DOI: 10.1182/blood-2004-01-0138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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