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Article

The Function of extravascular coagulation factor IX in haemostasis

29 Mar 2021

Abstract excerpt

Abstract Introduction The majority of clotting factor IX (FIX) resides extravascularly, in the subendothelial basement membrane, where it is important for haemostasis. Aim We summarize preclinical studies demonstrating extravascular FIX and its role in haemostasis and discuss clinical observations supporting this. We compare the in vivo binding of BeneFIX® and the extended half‐life FIX, Alprolix®, to...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 33780107
DOI: 10.1111/hae.14300

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