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Article

Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression.

BMC cell biology - 14 Jan 2017

Smith Elizabeth R, Meng Yue, Moore Robert, Tse Jeffrey D, Xu Arn G, Xu Xiang-Xi

Abstract excerpt

BACKGROUND: Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoderm cells. Here we further investigated the morphological changes of nuclei that accompany this...

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Identifiers

PMID: 28088180
DOI: 10.1186/s12860-017-0125-0
PMCID: PMC5237523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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