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Article

Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer.

The Journal of pathology - 1 Aug 2014

Loddo Marco, Andryszkiewicz Joanna, Rodriguez-Acebes Sara, Stoeber Kai, Jones Allison, Dafou Dimitra, Apostolidou Sophia, Wollenschlaeger Alex, Widschwendter Martin, Sainsbury Richard, Tudzarova Slavica, Williams Gareth Haydn

Abstract excerpt

Aberrant mitosis is a common feature of cancer, yet little is known about the altered genes causing mitotic defects. We screened human tumours for cells with morphological signatures of highly specific mitotic defects previously assigned to candidate genes in a genome-wide RNA interference screen carried out in HeLa cells (www.mitocheck.org). We discovered a striking enrichment of early mitotic configurations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 24931331
DOI: 10.1002/path.4393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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