Article
A genome-wide association study of acenocoumarol maintenance dosage.
Human molecular genetics - 1 Oct 2009
Teichert Martina, Eijgelsheim Mark, Rivadeneira Fernando, Uitterlinden Andre G, van Schaik Ron H N, Hofman Albert, De Smet Peter A G M, van Gelder Teun, Visser Loes E, Stricker Bruno H Ch
Abstract excerpt
Several genome-wide association studies have been performed on warfarin. For acenocoumarol, the most frequently used coumarin in many countries worldwide, pharmacodynamic influences are expected to be comparable. Pharmacokinetics however might differ. We aimed to confirm known or identify new genetic variants contributing to interindividual variation on stabilized acenocoumarol dosage by a GWAS. The index...
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