Article
Effect of CYP2C9, VKORC1, CYP4F2, and GGCX gene variants and patient characteristics on acenocoumarol maintenance dose: Proposal for a dosing algorithm for Moroccan patients.
Drug discoveries & therapeutics - 1 Jan 2000
Elkhazraji Abdelhak, Bouaiti El Arbi, Boulahyaoui Hassan, Nahmtchougli Christiana Philippa, Zahid Hafid, Bensaid Mounia, Ibrahimi Azeddine, Messaoudi Nezha
Abstract excerpt
We investigated the impact of non-genetics factors, and single nucleotide polymorphisms (SNPs) in VKORC1, CYP2C9, CYP4F2, and GGCX on acenocoumarol dosage in Moroccan adult's patients, in order to develop an algorithm to predict acenocoumarol dose for Moroccan patients. Our study consisted of 217 Moroccan patients taking a maintenance dose of acenocoumarol for various indications. The patients were genotyped for...
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