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Pharmacogenomics of anticoagulants: steps toward personal dosage

1 Jan 2009

Abstract excerpt

Warfarin and other coumarin anticoagulants are widely used clinically, but currently dosing is determined individually on the basis of patient response. There is increasing evidence that genetic factors, together with several non-genetic patient-specific factors, are important determinants of stable dose requirement for these compounds. Genotype for CYP2C9, which encodes the main cytochrome P450 enzyme that...

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PMID: 19348697
DOI: 10.1186/gm10

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