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Article

Influence of genetic and non-genetic factors on acenocoumarol maintenance dose requirement in a Tunisian population.

European journal of clinical pharmacology - 1 Jun 2018

Ajmi Marwa, Omezzine Asma, Achour Slim, Amor Dorra, Hamdouni Haithem, Ismaïl Fatma Ben Fredj, Rejeb Nabila Ben, Kechrid Chedia Laouani, Boughzela Essia, Bouslama Ali

Abstract excerpt

PURPOSE: We aimed to study potential variables involved in interindividual variability to acenocoumarol (AC) response in order to establish a pharmacogenetic algorithm (PA) that includes clinical and genetic factors to predict adequate AC dose to stabilize anticoagulation in a cohort of Tunisian patients. METHODS: Genotyping of the CYP2C9, VKORC1, CYP4F2, and CALU polymorphisms was conducted on 246 patients using...

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Identifiers

PMID: 29479633
DOI: 10.1007/s00228-018-2423-7

Genes

VKORC1
CALU

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