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Article

A novel, single algorithm approach to predict acenocoumarol dose based on CYP2C9 and VKORC1 allele variants.

PloS one - 18 Jun 2010

Verde Zoraida, Ruiz Jonatan R, Santiago Catalina, Valle Beatriz, Bandrés Fernando, Calvo Elpidio, Lucía Alejandro, Gómez Gallego Félix

Abstract excerpt

The identification of CYP2C9 and VKORC1 genes has strongly stimulated the research on pharmacogenetics of coumarins in the last decade. We assessed the combined influence of CYP2C9 *2 and *3, and VKORC1 c.-1639G>A, 497C>G, and 1173C>T variants, on acenocoumarol dosage using a novel algorithm approach, in 193 outpatients who had achieved stable anticoagulation. We constructed an "acenocoumarol-dose genotype score"...

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Source

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Identifiers

PMID: 20585445
DOI: 10.1371/journal.pone.0011210
PMCID: PMC2887839

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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