Article
The pediatric acenocoumarol dosing algorithm: the Children Anticoagulation and Pharmacogenetics Study.
Journal of thrombosis and haemostasis : JTH - 1 Sept 2018
Maagdenberg H, Bierings M B, van Ommen C H, van der Meer F J M, Appel I M, Tamminga R Y J, le Cessie S, Swen J J, van der Straaten T, de Boer A, Maitland-van der Zee A H
Abstract excerpt
Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed. We conducted a multicenter retrospective follow-up study in children in the Netherlands. Body surface area and indication explained 45.0% of the variability in dose requirement. Adding the genotypes of VKORC1, CYP2C9 and CYP2C18 to the algorithm increased this to 61.8%. SUMMARY: Background The large variability...
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