Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.

doi:10.1038/s41598-020-59641-9

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Article

Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.

Scientific reports - 18 Feb 2020

Cullell Natalia, Carrera Caty, Muiño Elena, Torres-Aguila Nuria-Paz, Cárcel-Márquez Jara, González-Sánchez Jonathan, Gallego-Fabrega Cristina, Molina Jessica, Besora Sarah, Sotoca Javier, Buongiorno Maria-Teresa, Jiménez-Conde Jordi, Giralt-Steinhauer Eva, de Torres-Chacón Reyes, Montaner Joan, Mancha Fernando, Cabezas Juan A, Martí-Fàbregas Joan, Prats-Sánchez Luis, Camps-Renom Pol, Purroy Francisco, Cambray Serafi, Freijo María Del Mar, Vives-Bauzá Cristòfol, Tur Silvia, Font Maria-Àngels, López-Cancio Elena, Hernandez-Perez Maria, Obach Victor, Calleja Ana, Arenillas Juan, Rodríguez-Yáñez Manuel, Castillo José, Sobrino Tomas, Fernández-Cádenas Israel, Krupinski Jerzy

Abstract excerpt

Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence,...

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Identifiers

PMID: 32071341
DOI: 10.1038/s41598-020-59641-9
PMCID: PMC7028945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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