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Article

In vitro characterization of a miR-122-sensitive double-helical switch element in the 5' region of hepatitis C virus RNA.

Nucleic acids research - 1 Sept 2009

Díaz-Toledano Rosa, Ariza-Mateos Ascensión, Birk Alex, Martínez-García Belén, Gómez Jordi

Abstract excerpt

It has been proposed that the hepatitis C virus (HCV) internal ribosome entry site (IRES) resides within a locked conformation, owing to annealing of its immediate flanking sequences. In this study, structure probing using Escherichia coli dsRNA-specific RNase III and other classical tools showed that this region switches to an open conformation triggered by the liver-specific microRNA, miR-122. This structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19578061
DOI: 10.1093/nar/gkp553
PMCID: PMC2760801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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