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Article

Activation of hepatitis c virus translation by a liver-specific microRNA

15 May 2009

Abstract excerpt

microRNAs (miRNAs) are involved in the regulation of translation of many mRNAs and affect cell cycle progression, differentiation and metabolism. The liver-specific microRNA-122 (miR-122) contributes to the liver tropism of Hepatitis C Virus (HCV) by accelerating the binding of ribosomes to the viral RNA and thereby stimulating HCV translation. Here, the most recent results on the molecular mechanisms of microRNA...

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PMID: 19372740
DOI: 10.4161/cc.8.10.8349

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