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Article

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

Molecular and cellular biology - 1 Nov 2005

Okamoto Koji, Kashima Kenji, Pereg Yaron, Ishida Michiko, Yamazaki Satomi, Nota Ayumi, Teunisse Amina, Migliorini Domenico, Kitabayashi Issay, Marine Jean-Christophe, Prives Carol, Shiloh Yosef, Jochemsen Aart G, Taya Yoichi

Abstract excerpt

Understanding how p53 activity is regulated is crucial in elucidating mechanisms of cellular defense against cancer. Genetic data indicate that Mdmx as well as Mdm2 plays a major role in maintaining p53 activity at low levels in nonstressed cells. However, biochemical mechanisms of how Mdmx regulates p53 activity are not well understood. Through identification of Mdmx-binding proteins, we found that 14-3-3...

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Identifiers

PMID: 16227609
DOI: 10.1128/MCB.25.21.9608-9620.2005
PMCID: PMC1265801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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