Article

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

2022-10-28

Abstract excerpt

<h4>Background</h4> Approximately half of all cancer patients receive radiotherapy and, as cancer survivorship rates increase with more effective therapies, the very low rate of radiation-associated sarcomas is rising. Radiation-associated sarcomas are life-threatening cancers, and radiation exposure is a primary risk factor for sarcoma development. During radiotherapy or other genotoxic cancer therapy for p53 m...

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Identifiers and source

Literature Corpus work: a8e77cc2-47b9-5065-8287-beef9037121f
DOI: 10.1101/2022.10.28.514234

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