Article

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

2024-09-25

Abstract excerpt

The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the GATA2 gene drive severe hematologic abnormalities and are associated with an increased risk of myelodysplastic syndromes and acute myeloid leukemia; however, the mechanisms underlying the pathophysiology of GATA2 deficiency remain still unclear. We developed two different mouse models that are based on serial and limiting d...

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Identifiers and source

Literature Corpus work: 782b644b-856f-50f3-ba2b-c180c0031e53
DOI: 10.1101/2024.09.24.614663

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