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Article

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.

ASN neuro - 14 Apr 2009

Greggio Elisa, Cookson Mark R

Abstract excerpt

Mutations in the gene encoding LRRK2 (leucine-rich repeat kinase 2) were first identified in 2004 and have since been shown to be the single most common cause of inherited Parkinson's disease. The protein is a large GTP-regulated serine/threonine kinase that additionally contains several protein-protein interaction domains. In the present review, we discuss three important, but unresolved, questions concerning...

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Identifiers

PMID: 19570025
DOI: 10.1042/AN20090007
PMCID: PMC2695577

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Source receipt: pubmed, retrieved 7 Sept 2026.

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