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Article

Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma.

International journal of cancer - 15 Dec 2009

Gaertner Florian C, Rohde Franziska, Mueller Jan, Blechert Birgit, Janssen Klaus-Peter, Essler Markus

Abstract excerpt

The sodium iodide symporter (NIS) mediates iodide uptake into the thyroid. Because of this mechanism, differentiated thyroid cancer is susceptible for radioiodine therapy. Functional NIS expression in extrathyroidal tumors has been reported mainly in breast cancer. We screened colorectal tumors for NIS expression and investigated the mechanisms regulating NIS activity. Cell lines were screened for iodide uptake...

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PMID: 19569179
DOI: 10.1002/ijc.24705

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APC
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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